Coro1b Gene Summary [Rat]
Enables Arp2/3 complex binding activity and cytoskeletal protein binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of lamellipodium morphogenesis; and negative regulation of smooth muscle cell chemotaxis. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Orthologous to human CORO1B (coronin 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coro1b |
| Official Name | coronin 1B [Source:RGD Symbol;Acc:2382] |
| Ensembl ID | ENSRNOG00000021828 |
| Bio databases IDs | |
| Aliases | coronin 1B |
| Synonyms | coronin 1B, CORONIN-2, coronin, actin binding protein 1B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Coro1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Type of WD40 repeat
- binding protein
- WD40 repeats
- cytoskeletal protein binding
- WD domain, G-beta repeat
- WD40
- protein binding
- Domain of unknown function (DUF1899)
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Rett syndrome
- hypersensitivity reaction type I
- passive cutaneous anaphylaxis
role in cell
- migration
- morphology
- organization
- degranulation
- morphogenesis
- chemotaxis by
- outgrowth
- assembly
- signal transduction in
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoskeleton
- cilia
- cell periphery
- perinuclear region
- Nucleus
- Plasma Membrane
- actin filaments
- cytosol
- growth cone
- nerve ending
- synapse
- actin stress fibers
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Coro1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament branching
- positive regulation of lamellipodium morphogenesis
- cellular response to platelet-derived growth factor stimulus
- actin filament organization
- wound healing
- ruffle organization
- negative regulation of smooth muscle cell chemotaxis
- endothelial cell chemotaxis
- cell migration
- actin cytoskeleton organization
- negative regulation of Arp2/3 complex-mediated actin nucleation
- actin filament bundle assembly
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- cell leading edge
- cytoplasm
- stress fiber
- cytosol
- actin filament
- plasma membrane
- lamellipodium
- cell periphery
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- protein binding
- cadherin binding
- Arp2/3 complex binding