Ssh1 Gene Summary [Rat]
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Involved in several processes, including excitatory chemical synaptic transmission; modulation of chemical synaptic transmission; and positive regulation of AMPA glutamate receptor clustering. Located in cell leading edge and growth cone. Orthologous to human SSH1 (slingshot protein phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ssh1 |
| Official Name | slingshot protein phosphatase 1 [Source:RGD Symbol;Acc:1306038] |
| Ensembl ID | ENSRNOG00000000695 |
| Bio databases IDs | |
| Aliases | slingshot protein phosphatase 1 |
| Synonyms | AW551225, Coronin, actin-binding protein 1c, Gm1394, Gm1395, slingshot protein phosphatase 1, SSH-1L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ssh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein phosphatase
- actin binding
- phosphatase
- DEK C terminal domain
- protein binding
- PTP_DSP_cys
- B domain of SSH1
- phosphatase domain
- A domain
Pathways
Biological processes and signaling networks where the Ssh1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astrocytosis
- axonal degeneration
- colorectal adenoma
- colorectal adenoma formation
- chronic lymphocytic leukemia
- microgliosis
role in cell
- expression in
- phosphorylation in
- formation
- binding in
- organization
- regression
- migration
- morphogenesis
- response by
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
- actin filaments
- midbody
- actin bundles
- cytosol
- growth cone
- cleavage furrow
- cellular protrusions
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ssh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein metabolic process
- negative regulation of actin filament polymerization
- cell morphogenesis
- positive regulation of synaptic plasticity
- protein dephosphorylation
- positive regulation of excitatory postsynaptic membrane potential
- cellular response to ATP
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoskeleton
- cytoplasm
- cleavage furrow
- midbody
- synapse
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding
- actin binding
- protein tyrosine phosphatase activity
- myosin phosphatase activity