Lrrtm4 Gene Summary [Rat]
Predicted to enable heparan sulfate proteoglycan binding activity. Acts upstream of or within synapse organization. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human LRRTM4 (leucine rich repeat transmembrane neuronal 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrtm4 |
| Official Name | leucine rich repeat transmembrane neuronal 4 [Source:RGD Symbol;Acc:1560707] |
| Ensembl ID | ENSRNOG00000021938 |
| Bio databases IDs | |
| Aliases | leucine rich repeat transmembrane neuronal 4 |
| Synonyms | 7530419J18Rik, A230052N11, leucine rich repeat transmembrane neuronal 4, RGD1560707 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrrtm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- binding protein
- ectodomain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- colorectal cancer
- hypotension
- insomnia
- Huntington disease
- acute myeloid leukemia
- peripheral arterial disease
- schizophrenia
- secondary thrombocytopenia
- pneumonia
role in cell
- formation
- development
- presynaptic differentiation
- function
- organization
- function in
- density
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synapse
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrrtm4 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- postsynaptic membrane
- extracellular matrix