Lrrtm4 Gene Summary [Mouse]
Enables heparan sulfate proteoglycan binding activity. Involved in regulation of synapse assembly. Acts upstream of or within AMPA glutamate receptor clustering; positive regulation of synapse assembly; and regulation of presynaptic membrane organization. Located in postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Is expressed in several structures, including central nervous system; embryo mesenchyme; and future midbrain. Orthologous to human LRRTM4 (leucine rich repeat transmembrane neuronal 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrtm4 |
| Official Name | leucine rich repeat transmembrane neuronal 4 [Source:MGI Symbol;Acc:MGI:2389180] |
| Ensembl ID | ENSMUSG00000052581 |
| Bio databases IDs | |
| Aliases | leucine rich repeat transmembrane neuronal 4 |
| Synonyms | 7530419J18Rik, A230052N11, leucine rich repeat transmembrane neuronal 4, RGD1560707 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrtm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- binding protein
- ectodomain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- colorectal cancer
- hypotension
- insomnia
- Huntington disease
- acute myeloid leukemia
- peripheral arterial disease
- schizophrenia
- secondary thrombocytopenia
- pneumonia
role in cell
- formation
- development
- presynaptic differentiation
- function
- organization
- function in
- density
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synapse
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrtm4 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- postsynaptic membrane
- extracellular matrix