Gpc4 Gene Summary [Rat]
Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of presynapse assembly. Is active in glutamatergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in Keipert syndrome. Orthologous to human GPC4 (glypican 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpc4 |
| Official Name | glypican 4 [Source:RGD Symbol;Acc:1359399] |
| Ensembl ID | ENSRNOG00000002413 |
| Bio databases IDs | |
| Aliases | glypican 4 |
| Synonyms | 9530073D23RIK, Glypican-4, K-glypican, KPTS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glypican
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Simpson-Golabi-Behmel syndrome type 1
- nasodigitoacoustic syndrome
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- hemimegalencephaly
- rheumatoid arthritis
- anemia
- craniosynostosis
- psoriatic arthritis
role in cell
- differentiation
- adhesion
- disruption
- assembly
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- glutaminergic synapse
- cell surface
- cellular membrane
- Nucleus
- plasma membrane extracellular face
- presynaptic membrane
- lysosomal compartment
- synaptosomes
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway
- cell migration
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- external side of plasma membrane
- lysosomal lumen
- synapse
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding