Lacc1 Gene Summary [Rat]
Predicted to enable adenosine deaminase activity; copper ion binding activity; and pentosyltransferase activity. Predicted to be involved in several processes, including positive regulation of cytokine production involved in immune response; regulation of cellular pH; and regulation of defense response. Predicted to be located in endoplasmic reticulum; nucleus; and peroxisome. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis. Orthologous to human LACC1 (laccase domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lacc1 |
| Official Name | laccase domain containing 1 [Source:RGD Symbol;Acc:1310185] |
| Ensembl ID | ENSRNOG00000022094 |
| Bio databases IDs | |
| Aliases | laccase domain containing 1 |
| Synonyms | 9030625A04Rik, C13orf31, FAMIN, FLJ38725, JUVAR, laccase domain containing 1, LOC100359875, RGD1310185 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lacc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 5'-methylthioadenosine phosphorylase
- polyphenol oxidase
- Multi-copper polyphenol oxidoreductase laccase
- purine-nucleoside phosphorylase
- adenosine deaminase
- enzyme
- protein binding
- CNF1_CheD_YfiH-like
- guanosine phosphorylase
Pathways
Biological processes and signaling networks where the Lacc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lacc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytokine production involved in immune response
- inflammatory response
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- innate immune response
- regulation of purine nucleotide metabolic process
- regulation of inflammatory response
- pattern recognition receptor signaling pathway
- regulation of cellular pH
Cellular Component
Where in the cell the gene product is active
- peroxisome
- nucleus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- deoxyadenosine deaminase activity
- protein binding
- S-methyl-5-thioadenosine phosphorylase activity
- copper ion binding
- guanosine phosphorylase activity
- oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
- adenosine deaminase activity
- purine-nucleoside phosphorylase activity