Dnmt3b Gene Summary [Rat]
Enables chromatin binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to hyperoxia; and response to vitamin A. Predicted to be located in chromosome, centromeric region; heterochromatin; and nucleoplasm. Predicted to be part of catalytic complex. Predicted to be active in nucleus. Biomarker of anxiety disorder; congenital heart disease; fetal alcohol spectrum disorder; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnmt3b |
| Official Name | DNA methyltransferase 3 beta [Source:RGD Symbol;Acc:1303274] |
| Ensembl ID | ENSRNOG00000010625 |
| Bio databases IDs | |
| Aliases | DNA methyltransferase 3 beta |
| Synonyms | DNA Methyltransferase 3B, DNA methyltransferase 3 beta, DNA methyltransferase 3 β, DNA MTase HsaIIIB, FSHD4, ICF, ICF1, M.HsaIIIB, MmuIIIB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnmt3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- transcription co-repressor
- PWWP domain
- histone deacetylase binding
- PWWP (Pro-Trp-Trp-Pro) domain
- chromatin binding
- enzyme
- protein binding
- AdoMet_MTases
- DNA (cytosine-5-)-methyltransferase
- DNA binding
- RNA binding
- Cysteine rich ADD domain in DNMT3
- FYVE domain like superfamily
- methyltransferase
- ATRX-homology domain
- DNA-methyltransferase (dcm)
Pathways
Biological processes and signaling networks where the Dnmt3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- non-Hodgkin disease
- squamous cell lung cancer
- hematologic cancer
- hematological neoplasia
- lung squamous cell carcinoma
role in cell
- expression in
- apoptosis
- growth
- quantity
- proliferation
- cell death
- cell cycle progression
- migration
- invasion by
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatin
- Cytoplasm
- Plasma Membrane
- cytoplasmic aggregates
- nuclear foci
- chromosome
- nucleoplasm
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnmt3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of gene expression
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA (cytosine-5-)-methyltransferase activity
- protein binding
- transcription corepressor activity
- metal ion binding
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
- DNA-methyltransferase activity