Plp2 Gene Summary [Rat]
This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | Plp2 |
| Official Name | proteolipid protein 2 [Source:RGD Symbol;Acc:1587363] |
| Ensembl ID | ENSRNOG00000039496 |
| Bio databases IDs | |
| Aliases | proteolipid protein 2 |
| Synonyms | A4, A4-LSB, mIMA4, proteolipid protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- chemokine binding
- ion transporter
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic injury
role in cell
- apoptosis
- abnormal morphology
- downregulation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- ion transport
- ion transmembrane transport
- cytokine-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemokine binding
- protein binding
- ion transmembrane transporter activity