Ccl20 Gene Summary [Rat]
Enables chemokine activity. Involved in cellular response to molecule of bacterial origin; chemotaxis; and positive regulation of interleukin-1 alpha production. Located in extracellular space. Used to study transient cerebral ischemia. Biomarker of brain ischemia and ulcerative colitis. Orthologous to human CCL20 (C-C motif chemokine ligand 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl20 |
| Official Name | C-C motif chemokine ligand 20 [Source:RGD Symbol;Acc:3646] |
| Ensembl ID | ENSRNOG00000015992 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 20 |
| Synonyms | C-C motif chemokine ligand 20, CHEMOKINE EXUDUS 1, CKb4, Exodus, exodus-1, LARC, Mip3, MIP-3A, MIP-3[a], MIP-3-alpha, MIP-3-α, SCYA20, ST38 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl20 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Inflammation in Asthma
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Docosahexaenoic Acid (DHA) Signaling
- Granulocyte Adhesion and Diapedesis
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- COVID-19
- atopic dermatitis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- production in
- expression in
- phosphorylation in
- activation in
- proliferation
- quantity
- migration
- adhesion
- activation
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccl20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell-cell signaling
- defense response to bacterium
- positive regulation of GTPase activity
- cell chemotaxis
- positive regulation of T cell migration
- chemotaxis
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- thymocyte migration
- T cell migration
- calcium-mediated signaling
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- chemokine activity
- CCR6 chemokine receptor binding