Hapln3 Gene Summary [Rat]
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to be located in membrane. Predicted to be active in extracellular space; perineuronal net; and synapse. Orthologous to human HAPLN3 (hyaluronan and proteoglycan link protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hapln3 |
| Official Name | hyaluronan and proteoglycan link protein 3 [Source:RGD Symbol;Acc:1308098] |
| Ensembl ID | ENSRNOG00000022321 |
| Bio databases IDs | |
| Aliases | hyaluronan and proteoglycan link protein 3 |
| Synonyms | 4930554N11Rik, EXLD1, HsT19883, hyaluronan and proteoglycan link protein 3, LP, Lpr3, OE-HABP, PROTEOGLYCAN LINK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hapln3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Link_Domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Extracellular link domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung carcinoma
- lung carcinoma process
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hapln3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- central nervous system development
- positive regulation of neuroblast proliferation
- cell adhesion
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perineuronal net
- synapse
Molecular Function
What the gene product does at the molecular level
- hyaluronic acid binding