Tnks1bp1 Gene Summary [Rat]
Predicted to enable ankyrin repeat binding activity; enzyme binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in cellular response to ionizing radiation and double-strand break repair. Predicted to be located in adherens junction and cytoplasm. Predicted to be part of CCR4-NOT complex. Predicted to be active in heterochromatin and nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnks1bp1 |
| Official Name | tankyrase 1 binding protein 1 [Source:RGD Symbol;Acc:1312021] |
| Ensembl ID | ENSRNOG00000009195 |
| Bio databases IDs | |
| Aliases | tankyrase 1 binding protein 1 |
| Synonyms | CNOT12, mKIAA1741, TAB182, tankyrase 1 binding protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnks1bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- binding protein
- tankyrase binding domain
- enzyme binding
- protein domain specific binding
- protein binding
- Tankyrase binding protein C terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- hypertrophic cardiomyopathy
role in cell
- expression in
- binding in
- migration
- proliferation
- olaparib resistance
- cisplatin resistance
- invasion by
- response by
- phosphorylation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- Plasma Membrane
- cytosol
- cell-cell adherens junctions
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnks1bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein autophosphorylation
- cellular response to ionizing radiation
- telomere maintenance via telomerase
- positive regulation of peptidyl-threonine phosphorylation
- nuclear-transcribed mRNA poly(A) tail shortening
- double-strand break repair
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- adherens junction
- cytoskeleton
- cytoplasm
- cytosol
- CCR4-NOT complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- ankyrin repeat binding
- enzyme binding