Pzp Gene Summary [Rat]

Enables brain-derived neurotrophic factor binding activity and nerve growth factor binding activity. Predicted to be involved in embryo implantation. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Pzp
Official Name
pregnancy-zone protein [Source:RGD Symbol;Acc:628643]
Ensembl ID
ENSRNOG00000006709
Bio databases IDs NCBI: 252922 Ensembl: ENSRNOG00000006709
Aliases pregnancy-zone protein
Synonyms A1m, A2m, Alpha 1 Macroglobulin, MAM, pregnancy-zone protein, PZP, alpha-2-macroglobulin like, PZP, α-2-macroglobulin like, α 1 Macroglobulin
Species
Rat, Rattus norvegicus
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pzp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • endopeptidase inhibitor
  • Alpha-2-macroglobulin bait region domain
  • ISOPREN_C2_like
  • binding protein
  • Macroglobulin domain MG4
  • A-macroglobulin TED domain
  • A-macroglobulin receptor binding domain
  • growth factor binding
  • Alpha-2-macroglobulin family
  • MG2 domain
  • Macroglobulin domain MG3

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • diabetic nephropathy
  • weight gain
  • pancreatitis
  • hepatic steatosis
regulated by
regulates
role in cell
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.