Fndc5 Gene Summary [Rat]
Predicted to enable hormone activity. Predicted to be involved in positive regulation of brown fat cell differentiation and response to muscle activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular region and plasma membrane. Orthologous to human FNDC5 (fibronectin type III domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fndc5 |
| Official Name | fibronectin type III domain containing 5 [Source:RGD Symbol;Acc:708525] |
| Ensembl ID | ENSRNOG00000030238 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 5 |
| Synonyms | 1500001L03Rik, D1MGI29, fibronectin type III domain containing 5, FRCP2, irisin, LOC260327, PeP, PXP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fndc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
- diabetes mellitus
- preeclampsia
- high-fat diet-induced obesity
- motor dysfunction
- Alzheimer disease
- end stage renal disease
- intrauterine growth retardation
- interstitial fibrosis
- osteolysis
role in cell
- expression in
- apoptosis
- cell death
- migration
- production in
- proliferation
- quantity
- invasion by
- morphology
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fndc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- positive regulation of brown fat cell differentiation
- signal transduction
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- hormone activity