Tor2a Gene Summary [Rat]
Predicted to enable hormone activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cAMP-mediated signaling; positive regulation of calcium ion transmembrane transport; and vasopressin secretion. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum lumen and nuclear envelope. Orthologous to human TOR2A (torsin family 2 member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tor2a |
| Official Name | torsin family 2, member A [Source:RGD Symbol;Acc:1359111] |
| Ensembl ID | ENSRNOG00000022514 |
| Bio databases IDs | |
| Aliases | torsin family 2, member A |
| Synonyms | Prosalusin, SALUSIN, TORP1, torsin family 2 member A, torsin family 2, member A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tor2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Torsin
- AAA domain (dynein-related subfamily)
- hormone
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute coronary syndrome
- bradycardia
- chronic stable angina
- hypotension
- postmyocardial infarction syndrome
- productive infection by HIV-1
role in cell
- expression in
- formation
- formation in
- accumulation in
- morphology
- blebbing in
- mitogenesis
- blebbing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tor2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- chaperone mediated protein folding requiring cofactor
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- hormone activity