Ifrd1 Gene Summary [Rat]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in glial cell proliferation and neuroblast proliferation. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in sarcoplasm. Predicted to be active in nucleus. Orthologous to human IFRD1 (interferon related developmental regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifrd1 |
| Official Name | interferon-related developmental regulator 1 [Source:RGD Symbol;Acc:2867] |
| Ensembl ID | ENSRNOG00000050997 |
| Bio databases IDs | |
| Aliases | interferon-related developmental regulator 1 |
| Synonyms | FRD1, Ifnl, interferon-related developmental regulator 1, LOC102551830, PC4, TIS7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ifrd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription factor binding
- Interferon-related developmental regulator (IFRD)
- Interferon-related protein conserved region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- organismal death
- systemic lupus erythematosus
- familial adenomatous polyposis
- amyotrophic lateral sclerosis
- cystic fibrosis
- epileptic seizure
role in cell
- expression in
- differentiation
- number
- cell death
- binding in
- fusion
- extension
- acetylation in
- osteoclastogenesis
- polarity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- sarcoplasm
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ifrd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myoblast cell fate determination
- negative regulation of collateral sprouting
- negative regulation of axon extension
- muscle cell differentiation
- striated muscle tissue development
- skeletal muscle tissue regeneration
Cellular Component
Where in the cell the gene product is active
- nucleus
- sarcoplasm