Acat1 Gene Summary [Rat]
Enables several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including adipose tissue development; liver development; and metanephric proximal convoluted tubule development. Located in mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acat1 |
| Official Name | acetyl-CoA acetyltransferase 1 [Source:RGD Symbol;Acc:2016] |
| Ensembl ID | ENSRNOG00000007862 |
| Bio databases IDs | |
| Aliases | acetyl-CoA acetyltransferase 1 |
| Synonyms | 3-Ketothiolase, 6330585C21Rik, ACAT, Acetyl-CoA acetlytransferase 1, acetyl-CoA acetyltransferase 1, acetyl-Coenzyme A acetyltransferase 1, Acyl-coa acetyltransferase, Acyl-coa acetyltransferase 1, LOC107984383, MAT, RATACAL, T2, THIL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- sterol O-acyltransferase
- acetyl-CoA acetyltransferases
- C-acetyltransferase
- acetyl-CoA C-acetyltransferase
- metal ion binding
- enzyme binding
- enzyme
- Beta-ketoacyl synthase, C-terminal domain
- identical protein binding
- cond_enzymes
- binding protein
- Thiolase, C-terminal domain
Pathways
Biological processes and signaling networks where the Acat1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- obesity
- hepatocellular carcinoma
- liver cancer
- alpha-methylacetoacetic aciduria
- hereditary disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
- atherosclerosis
role in cell
- expression in
- migration
- generation in
- invasion
- quantity
- proliferation
- cell death
- differentiation
- signaling in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- microsome
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
- cytoplasmic droplets
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process
- ketone body catabolic process
- response to starvation
- isoleucine catabolic process
- acetyl-CoA catabolic process
- response to organic cyclic compound
- response to hormone stimulus
- adipose tissue development
- fatty acid beta-oxidation
- liver development
- coenzyme A biosynthetic process
- coenzyme A metabolic process
- metanephric proximal convoluted tubule development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA C-acetyltransferase activity
- identical protein binding
- potassium ion binding
- C-acetyltransferase activity
- cholesterol O-acyltransferase activity
- enzyme binding