TOR2A Gene Summary [Human]
This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. The antimicrobial peptide salusin-beta has antibacterial activity. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | TOR2A |
| Official Name | torsin family 2 member A [Source:HGNC Symbol;Acc:HGNC:11996] |
| Ensembl ID | ENSG00000160404 |
| Bio databases IDs | |
| Aliases | torsin family 2 member A |
| Synonyms | Prosalusin, SALUSIN, TORP1, torsin family 2 member A, torsin family 2, member A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOR2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Torsin
- AAA domain (dynein-related subfamily)
- hormone
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute coronary syndrome
- bradycardia
- chronic stable angina
- hypotension
- postmyocardial infarction syndrome
- productive infection by HIV-1
role in cell
- expression in
- formation
- formation in
- accumulation in
- morphology
- blebbing in
- mitogenesis
- blebbing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOR2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- chaperone mediated protein folding requiring cofactor
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- hormone activity