Diaph3 Gene Summary [Rat]
Predicted to enable actin binding activity; microtubule binding activity; and protein homodimerization activity. Involved in spermatogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ESCRT I complex and filamentous actin. Predicted to be active in several cellular components, including cleavage furrow; cytoskeleton; and stereocilia tip-link density. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Diaph3 |
| Official Name | diaphanous-related formin 3 [Source:RGD Symbol;Acc:1593287] |
| Ensembl ID | ENSRNOG00000008986 |
| Bio databases IDs | |
| Aliases | diaphanous-related formin 3 |
| Synonyms | 4930417P13Rik, AN, AUNA1, DIA2, Diap3, diaphanous-related formin 3, DRF3, LOC101926912, mDIA2, NSDAN, p134MDia2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Diaph3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- GTPase binding domain
- Diaphanous FH3 Domain
- dimerization domain
- diaphanous autoregulatory domain
- coiled-coil domain
- enzyme
- protein binding
- formin homology domain 3
- Diaphanous GTPase-binding Domain
- formin homology domain 1
- microtubule binding
- Diaphanous inhibitory domain
- cytoskeletal protein binding
- actin binding
- protein homodimerization
- dia-autoinhibitory domain
Pathways
Biological processes and signaling networks where the Diaph3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- acute myeloid leukemia
- HER2 negative hormone receptor negative breast cancer
- colorectal cancer
- soft tissue sarcoma cancer
- small cell lung cancer
- non-insulin-dependent diabetes mellitus
- organismal death
- metabolic syndrome X
- pancreatic adenocarcinoma
role in cell
- formation
- activation in
- proliferation
- generation in
- disruption
- disruption in
- quantity
- induction in
- accumulation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Nucleus
- endosomes
- microtubules
- actin filaments
- midbody
- sarcomere
- microtubule organizing centers
- cytosol
- spindle pole
- cleavage furrow
- filopodial tip
- ribbon synapse
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Diaph3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear receptor cell differentiation
- head development
- cytoskeleton organization
- cell projection organization
- actin filament polymerization
- chromosome segregation
- negative regulation of microtubule depolymerization
- microtubule polymerization
- sensory perception of sound
- actin crosslink formation
- integrin-mediated signaling pathway
- in utero embryonic development
- actin nucleation
- enucleation
- endosomal transport
- establishment of cell polarity
- gene expression
- macromolecular complex remodeling
- actin cytoskeleton organization
- podosome assembly
- actin filament bundle assembly
- macrophage differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule organizing center
- cytoplasm
- cleavage furrow
- ESCRT I complex
- spindle pole
- actin filament bundle
- cytosol
- filamentous actin
- actin filament
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- actin binding
- cadherin binding
- small GTPase binding
- microtubule binding