Pphln1 Gene Summary [Rat]
Predicted to be involved in constitutive heterochromatin formation and protein localization to heterochromatin. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in nucleoplasm. Orthologous to human PPHLN1 (periphilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pphln1 |
| Official Name | periphilin 1 [Source:RGD Symbol;Acc:1306207] |
| Ensembl ID | ENSRNOG00000022778 |
| Bio databases IDs | |
| Aliases | periphilin 1 |
| Synonyms | 1110063K05RIK, 1600022A19RIK, CR, HSPC206, HSPC232, periphilin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pphln1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lge1_periphilin-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pphln1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- negative regulation of transcription, DNA-dependent
- keratinization
- positive regulation of methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi apparatus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding