Cdk6 Gene Summary [Rat]
Enables cyclin binding activity. Involved in DNA damage response. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D1-CDK6 complex; cyclin D2-CDK6 complex; and cyclin D3-CDK6 complex. Predicted to be active in cytoplasm and nucleus. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk6 |
| Official Name | cyclin-dependent kinase 6 [Source:RGD Symbol;Acc:621121] |
| Ensembl ID | ENSRNOG00000009258 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 6 |
| Synonyms | 5830411I20, AI504062, Crk2, cyclin-dependent kinase 6, FLJ31360, MCPH12, PLSTIRE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- p16INK4a-binding domain
- ATP-binding domain
- cyclin D1-binding domain
- ATP binding
- protein binding
- Protein kinase domain
- cyclin binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- ATP transfer region
Pathways
Biological processes and signaling networks where the Cdk6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Cell Cycle Control of Chromosomal Replication
- Cell Cycle: G1/S Checkpoint Regulation
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- atrial fibrillation
- ischemic stroke
- metastatic colorectal adenocarcinoma
- gastric cancer
- pancreatic cancer
- epithelial cancer
- gastrointestinal tract cancer
- epithelial neoplasia
- gastrointestinal neoplasia
role in cell
- growth
- survival
- phosphorylation in
- expression in
- transactivation in
- apoptosis
- activation in
- invasion by
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- ruffle
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte development
- negative regulation of cell proliferation
- negative regulation of cell cycle
- generation of neurons
- protein phosphorylation
- response to virus
- regulation of erythrocyte differentiation
- negative regulation of osteoblast differentiation
- cell division
- negative regulation of transcription from RNA polymerase II promoter
- gliogenesis
- negative regulation of cell differentiation
- positive regulation of fibroblast proliferation
- G1/S transition of mitotic cell cycle
- regulation of cell cycle
- negative regulation of cellular senescence
- negative regulation of myeloid cell differentiation
- signal transduction
- T cell differentiation in thymus
- hemopoietic stem cell differentiation
- cell dedifferentiation
- dentate gyrus development
- negative regulation of monocyte differentiation
- type B pancreatic cell development
- lateral ventricle development
- Notch signaling pathway
- positive regulation of cell-matrix adhesion
- positive regulation of gene expression
- negative regulation of epithelial cell proliferation
- regulation of gene expression
- regulation of cell motility
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cyclin D3-CDK6 complex
- nucleus
- cyclin D2-CDK6 complex
- centrosome
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
- ruffle
- cytosol
- cyclin D1-CDK6 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin binding
- cyclin-dependent protein kinase activity