Rab34 Gene Summary [Rat]
Predicted to enable several functions, including GTP binding activity; GTP-dependent protein binding activity; and small GTPase binding activity. Involved in cellular response to glucose stimulus and positive regulation of protein secretion. Predicted to be located in several cellular components, including centriole; endosome; and ruffle. Predicted to be active in Golgi cisterna and phagocytic vesicle. Human ortholog(s) of this gene implicated in orofaciodigital syndrome XX. Orthologous to human RAB34 (RAB34, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab34 |
| Official Name | RAB34, member RAS oncogene family [Source:RGD Symbol;Acc:1305058] |
| Ensembl ID | ENSRNOG00000023375 |
| Bio databases IDs | |
| Aliases | RAB34, member RAS oncogene family |
| Synonyms | NARR, OFD20, RAB34, member RAS oncogene family, RAB39, RAH, Rah1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab34 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- enzyme binding
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- guanyl nucleotide binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab34 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Jeune syndrome
- orofaciodigital syndrome type 20
- obesity
- atopic dermatitis
regulates
- Vsvg
- dextran
role in cell
- activation
- formation
- quantity
- maturation
- redistribution
- response by
- ciliogenesis in
- positioning
- ruffling
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane vesicles
- mother centriole
- ruffle
- perinuclear region
- vesicles
- Golgi Apparatus
- centriole
- cytosol
- membrane ruffles
- Golgi stacks
- cis Golgi networks
- early endosomes
- late endosomes
- peri-Golgi vesicles
- cytoplasmic vesicles
- Golgi cisternae
- phagosomes
- macropinosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab34 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- macropinocytosis
- cilium morphogenesis
- positive regulation of smoothened signaling pathway
- antigen processing and presentation
- phagosome-lysosome fusion
- Golgi to plasma membrane protein transport
- phagosome maturation
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- centriole
- phagocytic vesicle
- cilium
- ruffle membrane
- vesicle
- phagocytic vesicle membrane
- Golgi apparatus
- Golgi cisterna
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small GTPase binding
- GTP-dependent protein binding