Mbd1 Gene Summary [Rat]
Enables chromatin binding activity. Involved in several processes, including negative regulation of astrocyte differentiation; regulation of gene expression; and response to estradiol. Located in chromatin. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MBD1 (methyl-CpG binding domain protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbd1 |
| Official Name | methyl-CpG binding domain protein 1 [Source:RGD Symbol;Acc:1305980] |
| Ensembl ID | ENSRNOG00000024104 |
| Bio databases IDs | |
| Aliases | methyl-CpG binding domain protein 1 |
| Synonyms | CXXC3, methyl-CpG binding domain protein 1, PCM1, RFT |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mbd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nuclear localization sequence
- chromatin binding
- protein binding
- DNA binding
- unmethylated CpG binding
- transcription repression domain
- zinc ion binding
- double-stranded DNA binding
- methyl-CpG binding
- CXXC zinc finger
- CXXC zinc finger domain
- MBD
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Mbd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
role in cell
- cell death
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- intracellular membrane-bounded organelle
- Cytoplasm
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear speckles
- nuclear matrix
- centromeric heterochromatin
- chromatin
- euchromatin compartments
- heterochromatic compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mbd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- ventricular cardiac muscle tissue development
- negative regulation of transcription, DNA-dependent
- neuron differentiation
- response to estradiol stimulus
- response to cocaine
- transcription from RNA polymerase II promoter
- negative regulation of astrocyte differentiation
- response to xenobiotic stimulus
- response to nutrient levels
- regulation of gene expression, epigenetic
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- intracellular membrane-bounded organelle
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- double-stranded methylated DNA binding
- protein binding
- unmethylated CpG binding
- chromatin binding
- methyl-CpG binding