Fcgr3a Gene Summary [Rat]
Predicted to enable IgE receptor activity and low-affinity IgG receptor activity. Involved in cellular response to lipopolysaccharide. Located in cell surface. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); graft-versus-host disease; and hematologic cancer (multiple). Orthologous to several human genes including FCGR3A (Fc gamma receptor IIIa). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcgr3a |
| Official Name | Fc fragment of IgG receptor IIIa [Source:RGD Symbol;Acc:1303067] |
| Ensembl ID | ENSRNOG00000024382 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor IIIa |
| Synonyms | 4833442P21Rik, CD16, CD16-2, Fc gamma receptor 3A, FcgammaRIIIA, FcgammaRIV, Fcgr3a, FCGR3B, FcgRIV, Fc receptor, IgG, low affinity IV, Fcrl3, Fc γ receptor 3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fcgr3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- signaling receptor activity
- binding protein
- immunoglobulin domain
- Immunoglobulin like
- IgG receptor
- Immunoglobulin I-set domain
- low affinity IgG receptor
- IgE receptor
- transmembrane receptor
- phosphatidylinositol binding
- T-cell surface glycoprotein CD3 delta chain
Pathways
Biological processes and signaling networks where the Fcgr3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- arthritis
- rheumatoid arthritis
- K/BxN serum transfer arthritis
- autoimmune hemolytic anemia
- nephrotoxic nephritis
regulates
- IgG
role in cell
- proliferation
- survival
- internalization by
- activation
- transcytosis by
- response
- depletion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face