Fcgr4

Enables IgE receptor activity and IgG receptor activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; neutrophil activation; and positive regulation of bone resorption. Acts upstream of or within T cell mediated cytotoxicity; granzyme-mediated programmed cell death signaling pathway; and protein transport. Located in cell surface and plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); graft-versus-host disease; and hematologic cancer (multiple). Orthologous to human FCGR3A (Fc gamma receptor IIIa) and FCGR3B (Fc gamma receptor IIIb). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcgr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fcgr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.