Col22a1 Gene Summary [Rat]
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human COL22A1 (collagen type XXII alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col22a1 |
| Official Name | collagen type XXII alpha 1 chain [Source:RGD Symbol;Acc:1309081] |
| Ensembl ID | ENSRNOG00000024824 |
| Bio databases IDs | |
| Aliases | collagen type XXII alpha 1 chain |
| Synonyms | 2310067L16RIK, Collagen Type XXII, collagen, type XXII, alpha 1, collagen type XXII alpha 1 chain, collagen, type XXII, α 1, collagen type XXII α 1 chain, Collagen XXII, LOC100293055 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col22a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor (vWF) type A domain
- LamG
- vWFA
- Collagen triple helix repeat (20 copies)
- von Willebrand factor type A domain
Pathways
Biological processes and signaling networks where the Col22a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- myotendinous junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col22a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent conferring tensile strength