Uqcrb Gene Summary [Rat]
Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Part of respiratory chain complex III. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex III deficiency nuclear type 3. Orthologous to human UQCRB (ubiquinol-cytochrome c reductase binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uqcrb |
| Official Name | ubiquinol-cytochrome c reductase binding protein [Source:RGD Symbol;Acc:1311971] |
| Ensembl ID | ENSRNOG00000024967 |
| Bio databases IDs | |
| Aliases | ubiquinol-cytochrome c reductase binding protein |
| Synonyms | 2210415M14Rik, MC3DN3, QCR7, QP-C, ubiquinol-cytochrome c reductase binding protein, UQBC, UQBP, UQCR6, Uqcrbl, UQPC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uqcrb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquinol-cytochrome-c reductase
- binding protein
- Ubiquinol-cytochrome C reductase complex 14kD subunit
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Uqcrb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- Alzheimer disease
- sarcoidosis
- Huntington disease
- insulin resistance
- nuclear type 3 mitochondrial complex III deficiency
- chronic kidney disease
role in cell
- growth
- survival
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uqcrb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxidative phosphorylation
- cellular respiration
- mitochondrial electron transport, ubiquinol to cytochrome c
- aerobic respiration
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrial respiratory chain complex III
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding