Abca13 Gene Summary [Rat]
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in ceramide transport; positive regulation of cholesterol transport; and positive regulation of synaptic vesicle endocytosis. Predicted to be located in intracellular vesicle. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Orthologous to human ABCA13 (ATP binding cassette subfamily A member 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abca13 |
| Official Name | ATP binding cassette subfamily A member 13 [Source:RGD Symbol;Acc:1305895] |
| Ensembl ID | ENSRNOG00000025645 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily A member 13 |
| Synonyms | 9830132L24, A930002G16Rik, ATP binding cassette subfamily A member 13, ATP-binding cassette, sub-family A member 13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abca13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphonate C-P lyase system protein PhnK
- LPS export ABC transporter ATP-binding protein
- nickel import ATP-binding protein NikD
- gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit
- daunorubicin resistance ABC transporter ATP-binding subunit
- retinal-specific rim ABC transporter
- nickel import ATP-binding protein NikE
- ABC transporter
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- prostate cancer
- diabetic nephropathy
- major depression
- acute myeloid leukemia
- progression free survival
- idiopathic inflammatory myopathy
- cleft palate
- cleft lip
- drug allergy
role in cell
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Plasma Membrane
- vesicles
- secretory granule membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abca13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- transmembrane transport
- positive regulation of synaptic vesicle endocytosis
- positive regulation of cholesterol transport
- ceramide transport
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- intracellular membrane-bounded organelle
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- lipid transporter activity