Kdm2b Gene Summary [Rat]
Predicted to enable several functions, including histone H3K36 demethylase activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including brain development; embryonic morphogenesis; and negative regulation of neuron apoptotic process. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; and positive regulation of stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of PcG protein complex. Used to study T-cell non-Hodgkin lymphoma. Orthologous to human KDM2B (lysine demethylase 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm2b |
| Official Name | lysine demethylase 2B [Source:RGD Symbol;Acc:1310217] |
| Ensembl ID | ENSRNOG00000025702 |
| Bio databases IDs | |
| Aliases | lysine demethylase 2B |
| Synonyms | CXXC2, Fbl10, F-box protein FBL10, FBXL10, JEMMA, JHDM1B, lysine demethylase 2B, lysine (K)-specific demethylase 2B, NDY1, PCCX2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kdm2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- CTD_KDM2A_2B-like
- nucleic acid binding
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- Jhy protein
- sequence-specific DNA binding
- Cupin-like domain
- RmlC-like cupin superfamily
- PHD-finger
- unmethylated CpG binding
- F-box domain
- zinc ion binding
- double-stranded DNA binding
- F-box-like
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- hypertension
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- major depression
- neoplastic cell transformation
- breast carcinoma
- hereditary disorder
role in cell
- proliferation
- differentiation
- expression in
- growth
- apoptosis
- quantity
- silencing in
- accumulation in
- migration
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kdm2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein demethylation
- spermatogenesis
- midbrain-hindbrain boundary morphogenesis
- third ventricle development
- initiation of neural tube closure
- regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- fourth ventricle development
- positive regulation of cell growth
- midbrain development
- lateral ventricle development
- chromatin remodeling
- forebrain development
- hindbrain development
- embryonic camera-type eye morphogenesis
- negative regulation of neural precursor cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- PcG protein complex
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- transcription cofactor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- unmethylated CpG binding
- histone demethylase activity
- rRNA binding
- histone demethylase activity (H3-K36 specific)