Kdm2b Gene Summary [Mouse]
The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | Kdm2b |
| Official Name | lysine (K)-specific demethylase 2B [Source:MGI Symbol;Acc:MGI:1354737] |
| Ensembl ID | ENSMUSG00000029475 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific demethylase 2B |
| Synonyms | CXXC2, Fbl10, F-box protein FBL10, FBXL10, JEMMA, JHDM1B, lysine demethylase 2B, lysine (K)-specific demethylase 2B, NDY1, PCCX2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- CTD_KDM2A_2B-like
- nucleic acid binding
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- Jhy protein
- sequence-specific DNA binding
- Cupin-like domain
- RmlC-like cupin superfamily
- PHD-finger
- unmethylated CpG binding
- F-box domain
- zinc ion binding
- double-stranded DNA binding
- F-box-like
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- hypertension
- cardiovascular disorder
- non-insulin-dependent diabetes mellitus
- major depression
- neoplastic cell transformation
- breast carcinoma
- hereditary disorder
role in cell
- proliferation
- differentiation
- expression in
- growth
- apoptosis
- quantity
- silencing in
- accumulation in
- migration
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein demethylation
- spermatogenesis
- midbrain-hindbrain boundary morphogenesis
- third ventricle development
- initiation of neural tube closure
- regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- fourth ventricle development
- positive regulation of cell growth
- midbrain development
- lateral ventricle development
- chromatin remodeling
- forebrain development
- hindbrain development
- embryonic camera-type eye morphogenesis
- negative regulation of neural precursor cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- PcG protein complex
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- transcription cofactor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- unmethylated CpG binding
- histone demethylase activity
- rRNA binding
- histone demethylase activity (H3-K36 specific)