LOC108348120 Gene Summary [Rat]
Predicted to be involved in several processes, including heart formation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein localization to chromatin. Predicted to act upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Predicted to be located in chromatin; endoplasmic reticulum; and nuclear inner membrane. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348120 |
| Official Name | LEM domain-containing protein 2-like [Source:RGD Symbol;Acc:11418040] |
| Ensembl ID | ENSRNOG00000025864 |
| Bio databases IDs | |
| Aliases | LEM domain-containing protein 2-like |
| Synonyms | BC026588, CTRCT42, dJ482C21.1, LEM2, LEM domain containing 2, LEM domain nuclear envelope protein 2, LOC108348120, MARUPS, NET25 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348120 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear localization sequence
- LEM
- protein binding
- LEM domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Marbach-Rustad progeroid syndrome
- juvenile-onset cataract 46
- insomnia
role in cell
- accumulation in
- differentiation
- organization
- invagination
- invagination in
- myogenesis
- hyperactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Endoplasmic Reticulum
- cytoplasmic aggregates
- inner nuclear membrane
- nuclear rim
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348120 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear envelope organization
- skeletal muscle cell differentiation
- heart formation
- negative regulation of MAPK cascade
- protein localization to chromatin
- nuclear membrane organization
- neurogenesis
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- nuclear inner membrane
- membrane
- spindle
- endoplasmic reticulum
- nuclear periphery
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding