Slc12a7 Gene Summary [Rat]
Predicted to enable potassium:chloride symporter activity and protein kinase binding activity. Involved in cell volume homeostasis. Predicted to be located in membrane and synapse. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human SLC12A7 (solute carrier family 12 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc12a7 |
| Official Name | solute carrier family 12 member 7 [Source:RGD Symbol;Acc:1359672] |
| Ensembl ID | ENSRNOG00000016372 |
| Bio databases IDs | |
| Aliases | solute carrier family 12 member 7 |
| Synonyms | D13Ertd261e, KCC4, solute carrier family 12 member 7, solute carrier family 12, member 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc12a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- amino acid permease
- protein binding
- potassium:chloride symporter
- transporter
- Solute carrier family 12
- K-Cl cotransporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- cervical carcinoma
- epithelial uterine cancer
- hearing loss
- sickle cell anemia
- ovarian carcinoma
- epithelial ovarian cancer
- latent tuberculosis
- renal tubular acidosis
- paroxysmal nocturnal hemoglobinuria
regulates
- rubidium
- K+
- ion
role in cell
- degeneration
- volume
- response by
- dipeptide repeat protein sensitivity
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc12a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- potassium ion transmembrane transport
- chloride ion homeostasis
- potassium ion homeostasis
- cellular response to glucose stimulus
- synaptic transmission
- cell volume homeostasis
Cellular Component
Where in the cell the gene product is active
- macromolecular complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- potassium:chloride symporter activity
- ammonium transmembrane transporter activity
- protein kinase binding