Igll1 Gene Summary [Rat]
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be part of IgG immunoglobulin complex. Human ortholog(s) of this gene implicated in agammaglobulinemia 2. Orthologous to several human genes including IGLL5 (immunoglobulin lambda like polypeptide 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igll1 |
| Official Name | immunoglobulin lambda-like polypeptide 1 [Source:RGD Symbol;Acc:2321140] |
| Ensembl ID | ENSRNOG00000025990 |
| Bio databases IDs | |
| Aliases | immunoglobulin lambda-like polypeptide 1 |
| Synonyms | IGL, Igll1, IGLV, immunoglobulin lambda-like polypeptide 1, immunoglobulin lambda like polypeptide 5, immunoglobulin λ-like polypeptide 1, immunoglobulin λ like polypeptide 5, VL-MAR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Igll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
Pathways
Biological processes and signaling networks where the Igll1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- mixed cellularity classical Hodgkin lymphoma
- mixed cell Hodgkin disease
- nodular sclerosis classical Hodgkin lymphoma
- nodular sclerosis Hodgkin disease
- diabetic nephropathy
- idiopathic pulmonary fibrosis
regulated by
- resiquimod
- CpG ODN 2006
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Igll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immunoglobulin mediated immune response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- IgG immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- antigen binding