IGLL5 Gene Summary [Human]
This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | IGLL5 |
| Official Name | immunoglobulin lambda like polypeptide 5 [Source:HGNC Symbol;Acc:HGNC:38476] |
| Ensembl ID | ENSG00000254709 |
| Bio databases IDs | |
| Aliases | immunoglobulin lambda like polypeptide 5 |
| Synonyms | IGL, Igll1, IGLV, immunoglobulin lambda-like polypeptide 1, immunoglobulin lambda like polypeptide 5, immunoglobulin λ-like polypeptide 1, immunoglobulin λ like polypeptide 5, VL-MAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGLL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- immunoglobulin domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- mixed cellularity classical Hodgkin lymphoma
- mixed cell Hodgkin disease
- nodular sclerosis classical Hodgkin lymphoma
- nodular sclerosis Hodgkin disease
- diabetic nephropathy
- idiopathic pulmonary fibrosis
regulated by
- resiquimod
- CpG ODN 2006
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGLL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immunoglobulin mediated immune response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- IgG immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- antigen binding