Pnpla4 Gene Summary [Rat]
Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA4 (patatin like phospholipase domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnpla4 |
| Official Name | patatin like phospholipase domain containing 4 [Source:RGD Symbol;Acc:1562200] |
| Ensembl ID | ENSRNOG00000026157 |
| Bio databases IDs | |
| Aliases | patatin like phospholipase domain containing 4 |
| Synonyms | DXS1283E, GS2, iPLA2eta, patatin like phospholipase domain containing 4, RGD1562200 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnpla4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acylglycerol O-acyltransferase
- Patatins and Phospholipases
- enzyme
- retinyl-palmitate esterase
- phospholipase A2
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Pnpla4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnpla4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid homeostasis
- retinol metabolic process
- triglyceride catabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- mitochondrion
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- mono-olein transacylation activity
- diolein transacylation activity
- retinyl-palmitate esterase activity
- all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
- triglyceride lipase activity
- acylglycerol O-acyltransferase activity