Ppcs Gene Summary [Rat]
Predicted to enable phosphopantothenate--cysteine ligase activity and protein homodimerization activity. Predicted to be involved in acetyl-CoA biosynthetic process; coenzyme A biosynthetic process; and heart process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2C. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppcs |
| Official Name | phosphopantothenoylcysteine synthetase [Source:RGD Symbol;Acc:1311399] |
| Ensembl ID | ENSRNOG00000008572 |
| Bio databases IDs | |
| Aliases | phosphopantothenoylcysteine synthetase |
| Synonyms | 6330579B17RIK, CMD2C, FLJ11838, phosphopantothenoylcysteine synthetase, RGD1311399 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppcs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK06732
- protein homodimerization
- enzyme
- phosphopantothenate-cysteine ligase
- identical protein binding
- DNA / pantothenate metabolism flavoprotein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppcs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process
- coenzyme A biosynthetic process
- heart process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- phosphopantothenate--cysteine ligase activity