Vrk3 Gene Summary [Rat]
Predicted to enable protein phosphatase activator activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in DNA damage response; signal transduction; and skeletal muscle tissue development. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vrk3 |
| Official Name | VRK serine/threonine kinase 3 [Source:RGD Symbol;Acc:1549692] |
| Ensembl ID | ENSRNOG00000026517 |
| Bio databases IDs | |
| Aliases | VRK serine/threonine kinase 3 |
| Synonyms | vaccinia related kinase 3, VRK serine/threonine kinase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vrk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- zinc-ribbon domain
- protein phosphatase binding
- protein phosphatase regulator
- phosphatase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vrk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- skeletal muscle tissue development
- negative regulation of ERK1 and ERK2 cascade
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein phosphatase binding
- protein binding
- protein serine/threonine kinase activity