Vrk3 Gene Summary [Mouse]
Enables protein phosphatase activator activity and protein phosphatase binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Used to study autism spectrum disorder. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vrk3 |
| Official Name | vaccinia related kinase 3 [Source:MGI Symbol;Acc:MGI:2182465] |
| Ensembl ID | ENSMUSG00000002205 |
| Bio databases IDs | |
| Aliases | vaccinia related kinase 3 |
| Synonyms | vaccinia related kinase 3, VRK serine/threonine kinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vrk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- zinc-ribbon domain
- protein phosphatase binding
- protein phosphatase regulator
- phosphatase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vrk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- skeletal muscle tissue development
- negative regulation of ERK1 and ERK2 cascade
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein phosphatase binding
- protein binding
- protein serine/threonine kinase activity