Kif7 Gene Summary [Rat]
Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; negative regulation of smoothened signaling pathway; and positive regulation of smoothened signaling pathway. Predicted to act upstream of or within aorta development; cardiac septum development; and coronary vasculature development. Predicted to be located in several cellular components, including ciliary basal body; ciliary tip; and fibrillar center. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif7 |
| Official Name | kinesin family member 7 [Source:RGD Symbol;Acc:1310310] |
| Ensembl ID | ENSRNOG00000026857 |
| Bio databases IDs | |
| Aliases | kinesin family member 7 |
| Synonyms | ACLS, AGBK, HLS2, JBTS12, kinesin family member 7, LOC254571, MMEDF, UNQ340 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kif7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Kinesin motor, catalytic domain
- microtubule binding
- Domain of unknown function (DUF4686)
- Myosin and Kinesin motor domain
- Kinesin motor domain
- protein binding
- identical protein binding
- microtubule motor protein
Pathways
Biological processes and signaling networks where the Kif7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acrocallosal syndrome
- hereditary disorder
- hydrolethalus syndrome type 2
- congenital heart disease
- male infertility
- exencephaly
- Joubert syndrome type 12
- preaxial polydactyly
- digenic Joubert syndrome 12/15
- macrocephaly with multiple epiphyseal dysplasia and distinctive facies
regulates
- GLI:SUFU
- hedgehog
- GLI
- GLI2
role in cell
- differentiation
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- fibrillar center
- intracellular membrane-bounded organelle
- ciliary tip
- cilia
- basal bodies
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kif7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smoothened signaling pathway
- microtubule-based movement
- negative regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium basal body
- cilium
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding