Krt18 Gene Summary [Rat]
Predicted to enable scaffold protein binding activity. Involved in several processes, including cholangiocyte apoptotic process; hepatocyte differentiation; and response to fructose. Located in external side of plasma membrane; extracellular space; and keratin filament. Part of protein-containing complex. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in liver cirrhosis and metabolic dysfunction-associated steatohepatitis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt18 |
| Official Name | keratin 18 [Source:RGD Symbol;Acc:619935] |
| Ensembl ID | ENSRNOG00000047393 |
| Bio databases IDs | |
| Aliases | keratin 18 |
| Synonyms | 48-kD Keratin, CK-18, Ck D, CYK18, K18, K1cr, keratin 18, Keratin complex 1 acidic gene 18, KRT1-18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- O-GlcNAcylation site
- alpha helix
- tail domain
- TRADD binding domain
- protein binding
- Intermediate filament protein
- glycosylation site
- head domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the Krt18 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- neoplasia
- epithelial cancer
- cancer
- chromosomal instability
- asthma
- mucoepidermoid carcinoma
- bleeding
- mammary neoplasm
- heart failure
role in cell
- activation in
- apoptosis
- cytolysis
- cell death
- morphology
- quantity
- autophagy in
- degeneration
- migration
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cytoskeleton
- cell surface
- Extracellular Space
- cell periphery
- apical compartment
- cell cortex
- centrosome
- intermediate filaments
- keratin filament networks
- microtubule organizing centers
- cytosol
- plasma membrane extracellular face
- nucleoli
- nuclear matrix
- keratin intermediate filaments
- plasma
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- negative regulation of apoptotic process
- extrinsic apoptotic signaling pathway
- intermediate filament cytoskeleton organization
- Golgi to plasma membrane protein transport
- anatomical structure morphogenesis
- hepatocyte apoptotic process
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- intermediate filament
- nucleolus
- adherens junction
- keratin filament
- cytoskeleton
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- microtubule organizing center
- cytoplasm
- nuclear matrix
- cytosol
- cell periphery
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- RNA binding
- protein binding
- structural molecule activity