Cemip Gene Summary [Rat]
Predicted to enable several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Predicted to be involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of protein targeting to membrane. Predicted to be located in several cellular components, including clathrin-coated vesicle; endoplasmic reticulum; and nucleus. Orthologous to human CEMIP (cell migration inducing hyaluronidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cemip |
| Official Name | cell migration inducing hyaluronidase [Source:RGD Symbol;Acc:1305254] |
| Ensembl ID | ENSRNOG00000012442 |
| Bio databases IDs | |
| Aliases | cell migration inducing hyaluronidase |
| Synonyms | 12H19.01.T7, 6330404C01Rik, 9930013L23Rik, CCSP1, cell migration inducing hyaluronidase 1, cell migration inducing protein, hyaluronan binding, CEMIP1, HYBID, KIAA1199, RGD1305254, TMEM2L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cemip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G8 domain
- Mucin-2 protein WxxW repeating region
- ER retention sequence binding
- Interleukin-like EMT inducer
- clathrin binding
- enzyme
- protein binding
- hyalurononglucosaminidase
- hyaluronic acid binding
- Domains similar to the Pancreatic-derived factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- neoplasia
- breast cancer
- colorectal cancer
- metastatic colorectal cancer
- familial nonsyndromic hearing impairment
- peripheral arterial disease
- dextran sodium sulfate-induced colitis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- number
- migration
- degradation in
- catabolism in
- O-GlcNAcylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cytoplasmic vesicle membrane
- Extracellular Space
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- nuclear envelope
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cemip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- positive regulation of protein targeting to membrane
- positive regulation of protein kinase C activity
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of release of sequestered calcium ion into cytosol
- hyaluronan biosynthetic process
- positive regulation of cell migration
- hyaluronan catabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- coated pit
- endoplasmic reticulum
- clathrin-coated endocytic vesicle
- extracellular region
- fibrillar center
- plasma membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- hyalurononglucosaminidase activity
- protein binding
- hyaluronic acid binding
- carbohydrate binding
- ER retention sequence binding