Krt15 Gene Summary [Rat]
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Krt15 |
| Official Name | keratin 15 [Source:RGD Symbol;Acc:1303044] |
| Ensembl ID | ENSRNOG00000014099 |
| Bio databases IDs | |
| Aliases | keratin 15 |
| Synonyms | 50-kD Keratin, Basic cytokeratin, CK15, K15, K1CO, Ka15, keratin 15, KRT1-15 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- breast cancer
- atopic dermatitis
- eczema
- plaque psoriasis
- androgenic alopecia
- hypertrophic scarring
- chronic sinusitis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- membrane surface
- intermediate filaments
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- epidermis development
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoskeleton
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- structural constituent of cytoskeleton