Ptbp1 Gene Summary [Rat]
Enables DNA binding activity; RNA binding activity; and single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of insulin secretion; and regulation of gene expression. Located in neuron projection terminus. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptbp1 |
| Official Name | polypyrimidine tract binding protein 1 [Source:RGD Symbol;Acc:62047] |
| Ensembl ID | ENSRNOG00000010448 |
| Bio databases IDs | |
| Aliases | polypyrimidine tract binding protein 1 |
| Synonyms | AL033359, HNRNP-I, HNRPI, polypyrimidine tract binding protein 1, pPTB, PTB, PTB-1, PTB2, PTB3, PTB4, Pybp, Pybp1, Pybp2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- hnRNP-L/PTB/hephaestus splicing factor family
- RNA recognition motif
- nucleic acid binding
- mRNA binding
- nuclear localization sequence
- enzyme
- protein binding
- sequence-specific DNA binding
- single-stranded DNA specific endodeoxyribonuclease
- RNA binding
- RRM-like domain
- single-stranded DNA binding
- poly-pyrimidine tract binding
Pathways
Biological processes and signaling networks where the Ptbp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- breast cancer
- metastasis
- glaucoma
- open-angle glaucoma
- epithelial ovarian cancer
- refractive error
- ventricular noncompaction
role in cell
- expression in
- invasion by
- proliferation
- production in
- migration
- growth
- quantity
- differentiation
- cisplatin sensitivity
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein fractions
- nuclear fraction
- polyribosome fractions
- cytosol
- nuclear foci
- perinucleolar compartments
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nerve ending
- paraspeckle-like structures
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of muscle cell differentiation
- RNA splicing
- regulation of cell differentiation
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of nuclear mRNA splicing, via spliceosome
- regulation of RNA splicing
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of protein dephosphorylation
- mRNA processing
- negative regulation of RNA splicing
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- membrane
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- protein binding
- RNA binding
- poly-pyrimidine tract binding
- mRNA binding