Clrn2 Gene Summary [Rat]
Predicted to be involved in auditory receptor cell stereocilium organization. Predicted to act upstream of or within inner ear auditory receptor cell differentiation; sensory perception of sound; and stereocilium maintenance. Predicted to be located in stereocilium bundle. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human CLRN2 (clarin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clrn2 |
| Official Name | clarin 2 [Source:RGD Symbol;Acc:1591112] |
| Ensembl ID | ENSRNOG00000027195 |
| Bio databases IDs | |
| Aliases | clarin 2 |
| Synonyms | clarin 2, DFNB117, EG624224, LOC681950, mpc169H |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clrn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- stereocilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clrn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- auditory receptor cell stereocilium organization
Cellular Component
Where in the cell the gene product is active
- stereocilium bundle
- stereocilium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding