Ubac2 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Predicted to act upstream of or within protein localization to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Orthologous to human UBAC2 (UBA domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubac2 |
| Official Name | UBA domain containing 2 [Source:RGD Symbol;Acc:1311689] |
| Ensembl ID | ENSRNOG00000012710 |
| Bio databases IDs | |
| Aliases | UBA domain containing 2 |
| Synonyms | 1190008A14Rik, PHGDHL1, UBA domain containing 2, ubiquitin associated domain containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ubac2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- enzyme
- protein binding
- phosphoglycerate dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- asthma
- peripheral arterial disease
- psoriasis
- epithelial basal cell carcinoma
- Crohn disease
- inflammatory bowel disease
- respiratory disorder
- systemic lupus erythematosus
- hypothyroidism
role in cell
- expression in
- production in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ubac2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- protein localization in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding