Myo7a Gene Summary [Rat]
Enables several functions, including adenyl ribonucleotide binding activity; calmodulin binding activity; and identical protein binding activity. Involved in actin filament-based movement. Located in upper tip-link density. Part of myosin VII complex. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo7a |
| Official Name | myosin VIIA [Source:RGD Symbol;Acc:628830] |
| Ensembl ID | ENSRNOG00000013641 |
| Bio databases IDs | |
| Aliases | myosin VIIA |
| Synonyms | DFNA11, DFNB2, Hdb, Myo7, myosin VIIA, MYOVIIA, MYU7A, nmf371, NSRD2, polka, sh-1, USH1B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myo7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arginine and glutamate-rich 1
- UDM1_RNF168_RNF169-like
- ADP binding
- ATP binding
- rRNA-processing protein Efg1
- microfilament motor protein
- spectrin binding
- coiled-coil domain
- enzyme
- motor domain
- identical protein binding
- MyTH4 domain
- FERM domain
- Vacuolar (H+)-ATPase G subunit
- Calmodulin-binding motif
- Coiled-coil domain-containing protein 50 N-terminus
- actin binding
- IQ domain
- tail domain
- FERM domain B-lobe
- FERM central domain
- Band 4.1 homologues
- calmodulin binding
- PspA/IM30 family
- Myosin and Kinesin motor domain
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- Myosin head (motor domain)
- Src Homology 3 domain superfamily
- IQ calmodulin-binding motif
- actin filament binding
- binding protein
- Ubl1_cv_Nsp3_N-like
- motor protein
- Myosin
- Coiled-coil domain-containing protein 66
Pathways
Biological processes and signaling networks where the Myo7a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 2
- ear malformation
- Usher syndrome type 1B
- Usher syndrome type 1
- Usher syndrome
- retinal dystrophy
- autosomal dominant 11 deafness
- Usher syndrome type 2
- autosomal recessive deafness
- hereditary disorder
role in cell
- accumulation
- accumulation in
- phagocytosis by
- survival
- quantity
- differentiation
- degeneration
- depolarization
- aggregation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- kinocilia
- cilia
- apical compartment
- membrane surface
- vesicles
- lysosome
- cytosol
- connecting cilia
- stereocilia
- lateral cell surfaces
- apical membrane
- plasma membrane projections
- lysosome membrane
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- cuticular plate
- melanosomes
- anchoring junction
- microvilli
- perikaryon
- exosomes
- cell-cell adherens junctions
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myo7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- auditory receptor cell stereocilium organization
- lysosome organization
- cochlea development
- protein localization
- eye photoreceptor cell development
- actin filament organization
- visual perception
- endocytosis
- intracellular protein transport
- sensory organ development
- sensory perception of sound
- mechanoreceptor differentiation
- phagolysosome assembly
- equilibrioception
- pigment granule transport
- actin filament-based movement
- sensory perception of light stimulus
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- synapse
- lysosomal membrane
- photoreceptor outer segment
- cytoplasm
- microvillus
- melanosome
- cell cortex
- membrane
- actin cytoskeleton
- cytosol
- stereocilium
- photoreceptor inner segment
- myosin VII complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein domain specific binding
- identical protein binding
- calmodulin binding
- protein binding
- spectrin binding
- ADP binding
- microfilament motor activity