Lilrb4 Gene Summary [Rat]
Predicted to enable several functions, including apolipoprotein binding activity; fibronectin binding activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; regulation of leukocyte activation; and regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lilrb4 |
| Official Name | leukocyte immunoglobulin like receptor B4 [Source:RGD Symbol;Acc:1359090] |
| Ensembl ID | ENSRNOG00000027811 |
| Bio databases IDs | |
| Aliases | leukocyte immunoglobulin like receptor B4 |
| Synonyms | CD85K, gp49, Gp49a, Gp49b, GP49B2, HM18, ILT3, leukocyte immunoglobulin like receptor B4, leukocyte immunoglobulin-like receptor, subfamily B, member 4A, leukocyte immunoglobulin-like receptor, subfamily B, member 4B, Lilr4b, Lilrb4, Lilrb4a, Lilrb4b, LIR-5, LOC499078 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lilrb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoreceptor tyrosine-based inhibition motif
- cytoplasmic domain
- protein phosphatase binding
- transmembrane receptor protein tyrosine kinase inhibitor activity
- immunoglobulin domain
- protein tyrosine kinase inhibitor activity
- transmembrane domain
- integrin binding
- receptor inhibitor
- protein binding
- fibronectin binding
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- insulin-dependent diabetes mellitus
- tauopathy
- hypersensitivity reaction type I
- passive cutaneous anaphylaxis
- graft-vs-host disease
- amyloidosis
- multiple system atrophy
role in cell
- expression in
- activation
- production in
- proliferation
- differentiation
- response
- number
- function
- degranulation
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face