Lilrb4a Gene Summary [Mouse]
Enables fibronectin binding activity; integrin binding activity; and protein phosphatase binding activity. Involved in negative regulation of immunoglobulin production and negative regulation of leukocyte activation. Acts upstream of or within several processes, including alpha-beta T cell proliferation; cellular response to lipopolysaccharide; and response to nematode. Located in external side of plasma membrane. Is expressed in urinary system. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lilrb4a |
| Official Name | leukocyte immunoglobulin-like receptor, subfamily B, member 4A [Source:MGI Symbol;Acc:MGI:102701] |
| Ensembl ID | ENSMUSG00000112148 |
| Bio databases IDs | |
| Aliases | leukocyte immunoglobulin-like receptor, subfamily B, member 4A |
| Synonyms | CD85K, gp49, Gp49a, Gp49b, GP49B2, HM18, ILT3, leukocyte immunoglobulin like receptor B4, leukocyte immunoglobulin-like receptor, subfamily B, member 4A, leukocyte immunoglobulin-like receptor, subfamily B, member 4B, Lilr4b, Lilrb4, Lilrb4a, Lilrb4b, LIR-5, LOC499078 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lilrb4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoreceptor tyrosine-based inhibition motif
- cytoplasmic domain
- protein phosphatase binding
- transmembrane receptor protein tyrosine kinase inhibitor activity
- immunoglobulin domain
- protein tyrosine kinase inhibitor activity
- transmembrane domain
- integrin binding
- receptor inhibitor
- protein binding
- fibronectin binding
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- insulin-dependent diabetes mellitus
- tauopathy
- hypersensitivity reaction type I
- passive cutaneous anaphylaxis
- graft-vs-host disease
- amyloidosis
- multiple system atrophy
role in cell
- expression in
- activation
- production in
- proliferation
- differentiation
- response
- number
- function
- degranulation
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face