Fnip2 Gene Summary [Rat]
Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of TORC1 signaling; and regulation of primary metabolic process. Predicted to act upstream of or within with a positive effect on negative regulation of cell population proliferation. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of FNIP-folliculin RagC/D GAP. Predicted to be active in cytoplasm. Orthologous to human FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fnip2 |
| Official Name | folliculin interacting protein 2 [Source:RGD Symbol;Acc:1562174] |
| Ensembl ID | ENSRNOG00000027833 |
| Bio databases IDs | |
| Aliases | folliculin interacting protein 2 |
| Synonyms | D630023B12Rik, FNIPL, folliculin interacting protein 2, MAPO1, mKIAA1450, RGD1562174 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fnip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Folliculin-interacting protein C-terminus
- Folliculin-interacting protein N-terminus
- ATPase inhibitor activity
- Folliculin-interacting protein middle domain
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- insomnia
- mucopolysaccharidosis type IVB
- renal neoplasia
role in cell
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fnip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of protein phosphorylation
- DNA damage response, signal transduction resulting in induction of apoptosis
- protein phosphorylation
- positive regulation of protein complex assembly
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- centriolar satellite
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase inhibitor activity
- chaperone binding