FNIP2 Gene Summary [Human]
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | FNIP2 |
| Official Name | folliculin interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:29280] |
| Ensembl ID | ENSG00000052795 |
| Bio databases IDs | |
| Aliases | folliculin interacting protein 2, O6-methylguanine-induced apoptosis 1 |
| Synonyms | D630023B12Rik, FNIPL, folliculin interacting protein 2, MAPO1, mKIAA1450, RGD1562174 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FNIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Folliculin-interacting protein C-terminus
- Folliculin-interacting protein N-terminus
- ATPase inhibitor activity
- Folliculin-interacting protein middle domain
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- insomnia
- mucopolysaccharidosis type IVB
- renal neoplasia
role in cell
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FNIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of protein phosphorylation
- DNA damage response, signal transduction resulting in induction of apoptosis
- protein phosphorylation
- positive regulation of protein complex assembly
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- centriolar satellite
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ATPase inhibitor activity
- chaperone binding