Ankrd11 Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including face morphogenesis; neural crest cell differentiation; and skeletal system development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin. Human ortholog(s) of this gene implicated in KBG syndrome. Orthologous to human ANKRD11 (ankyrin repeat domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ankrd11 |
| Official Name | ankyrin repeat domain 11 [Source:RGD Symbol;Acc:1306679] |
| Ensembl ID | ENSRNOG00000027906 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 11 |
| Synonyms | 2410104C19Rik, 3010027A04RIK, 6330578C09Rik, 9530048I21Rik, AA930108, ANCO-1, ankyrin repeat domain 11, ankyrin repeat domain containing 11, Gm176, LOC629623, LZ16, T13, Yod |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ankrd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein homodimerization
- identical protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- epithelial cancer
- cancer
- asthma
- COVID-19
- KBG syndrome
- mental retardation
- hereditary disorder
- Huntington disease
- global developmental delay
regulated by
- beta-estradiol
- RNF187
role in cell
- migration
- proliferation
- invasion by
- ossification by
- recruitment in
- trimethylation in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ankrd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- odontogenesis of dentin-containing tooth
- skeletal system morphogenesis
- face morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm